Life Sciences - DNA Guided Superfoods
Your Foundation for Optimal Wellness
How does the company plan to ensure my confidential information
is kept private? GeneLink respects the privacy of every individual
and has taken numerous precautions to create a process that will
allow individuals to maintain the highest level of privacy. All
information provided by the customer is kept on a secure server
and all samples are identified by barcode only. Your private information
is never shared with a third-party. GeneLink maintains a strict
confidentiality policy. After the evaluation is completed, all
DNA sample material is destroyed.
are the details of the SNP analysis process?
1. After receiving the swabs, GeneLink’s lab extracts the
DNA. (All samples are bar coded for confidentiality and control).
2. Next, the lab amplifies the region of the DNA containing the
SNP (single nucleotide polymorphism) using what is called a PCR
(polymerase chain reaction). 3. The SNP is measured by a single
nucleotide base extensions method called SNP-IT™ Technology.
4. The results of these SNP measurements are translated by GeneLink’s
computers and developed in to a confidential report called a Nutragenetic
accurate is this testing technology?
There are several types of methods to determine DNA polymorphisms
(SNPs). GeneLink utilizes the Single Base Chain Extension
(SBCE) assay which is the most accurate method available
to detect single nucleotide polymorphisms. The SBCE assay
identifies the (SNP) directly on the DNA. The profile accuracy
is nearly 100%. The assay is performed robotically, which
virtually eliminates human error in sample manipulation.
In rare instances, when a particular SNP area of a profile
‘does not read,’ it is repeated. All repeats
thus far have been successful.
is the science behind the determination of a need for
Basic Support, Added support and Maximum support?
There are two copies of every gene, one from each parent.
The SNP analysis examines each copy. Moreover, for each
gene copy, the SNP will exist as either variant A (e.g.,
desirable) or variant B (e.g., undesirable). All individuals
will end up with SNP reads of: A/A or A/B or B/B. In this
case: If a person has B/B (Maximum Support is suggested)
because that person has two undesirable SNPs. If a person
has A/B (which is less desirable - Added Support is suggested)
because that person has only one of the desirable SNPs
and an undesirable SNP. If a person has A/A (Basic Support
is recommended) the person receives a basic formulation.
(GeneLink agrees with the Journal of American Medicine,
The Council for Responsible Nutrition and studies demonstrating
that everyone benefits from at least a basic nutritional
supplementation or skin-care protection). GeneLink’s
statistical results demonstrate that virtually everyone
tested will require Added Support and/or Maximum Support
in at least one or two gene SNP areas.
are the SNPs used in GeneLink’s profiles selected
over millions of others?
There are millions of SNPs. However, only certain subsets
are associated with increased risk for disease and physiologic
health conditions. GeneLink selects only ‘functional
SNPs’ which indicate poor enzyme function via epidemiological
or biochemical studies. Additionally, GeneLink selects
only those SNPs which can be addressed using nutrients
or formulations or lifestyle modifications. These SNPs
physically reside in either the coding region (protein
portion) of the gene which can alter enzyme function or
they reside in the promoter region which affects the level
of expression of the gene in question.
is the clinical research that ties nutritional supplements
and topical skin treatments to support SNP predispositions?
All of the enzymes represented in the SNP profile have
been well-studied and there is biochemical evidence in
almost every instance that correlates why an enzyme affected
by the SNP does not function properly. Additionally, there
is leading clinical evidence linking SNPs to nutrition.
Thus, for major enzymatic players of oxidative stress,
there is a clear fit with the genetics, epidemiology and
biochemistry. For several of the SNPs, there is a direct
link between having the SNP and being able to lower oxidative
stress or the potential health risks associated with oxidative
stress by the ingestion or application of particular antioxidant
nutrients and active ingredients. For example the SNP
for methylenetetrahyrofolate reductase (MTHFR or Heart,
Circulatory Health-2), produces an enzyme with decreased
affinity (Km) for its direct substrate, 5,10 methylene-THF,
which can cause a build up of homocysteine, which is deleterious
to heart health. Increasing folic acid (upstream substrate)
or the product of the enzyme reaction (5 methyl-THF) can
ameliorate the build-up of homocysteine. For some SNPs
there is no definitive clinical evidence available to
date that directly links the benefit of a nutrient to
the SNP. These studies will come in time. Nevertheless,
the fact that the biochemical parameters for all of the
SNPs are so well known provides a rational nutritional
approach to addressing unfavorable physiological conditions,
based on scientific knowledge of how the SNP specifically
conducted the research and who endorses GeneLink’s
GeneLink’s medical and scientific advisors along
with independent academic laboratories and medical centers
have conducted nearly 100% of the work. GeneLink’s
medical and scientific advisors hold positions at major
research institutions. The science and technical information
behind GeneLink’s technology has been favorably
reviewed by the scientific staff department of our various
clients and collaborative partners. Studies have been
statistically quantified and involve sophisticated molecular
biology, biochemistry and genetic analyses.
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